Oxaloacetic acid

≥97% (HPLC)

Sinônimo(s):

2-Oxosuccinic acid, Ketosuccinic acid, Oxalacetic acid, Oxobutanedioic acid

Fórmula linear:

HOOCCH₂COCOOH

Número CAS:

328-42-7

Peso molecular:

132.07

Beilstein:

1705475

Número EC:

206-329-8

Número MDL:

MFCD00002592

ID de substância PubChem:

24897993

NACRES:

NA.32

Nível de qualidade

200

Ensaio

≥97% (HPLC)

forma

powder

solubilidade

H₂O: 100 mg/mL, clear to slightly hazy, colorless to light yellow

temperatura de armazenamento

−20°C

SMILES string

OC(=O)CC(=O)C(O)=O

InChI

1S/C4H4O5/c5-2(4(8)9)1-3(6)7/h1H2,(H,6,7)(H,8,9)

InChI key

KHPXUQMNIQBQEV-UHFFFAOYSA-N

Descrição geral

Oxaloacetic acid is a dicarboxylic acid. It is an intermediate in the citric acid cycle. It is highly soluble in water and is present ubiquitously. It is produced in the mitochondria by the action of pyruvate carboxylase on pyruvate. Breakdown products of oxaloacetate includes malate, pyruvate and aspartic acid.[1]

Aplicação

Oxaloacetic acid has been used as a substrate for measuring citrate synthase activity in cybrids[2] and neuroblastoma cells.[3] It has also been used for measuring malate dehydrogenase reactivation.[4]

Ações bioquímicas/fisiológicas

Oxaloacetic acid being an intermediate in the tri carboxylic cycle is central to metabolism. It is part of gluconeogenesis pathway. Mutation in pyruvate carboxylase leads to decreased production of oxaloacetate.[1] It inhibits succinate dehydrogenase and is a key regulator of mitochondrial metabolism.[5]