Sinônimo(s):

DMBA, 1,4-Dimethyl-2,3-benzophenanthrene, 9,10-Dimethyl-1,2-benzanthracene

Empirical Formula (Hill Notation):

C₂₀H₁₆

Número CAS:

57-97-6

Peso molecular:

256.34

Beilstein:

1912135

Número EC:

200-359-5

Número MDL:

MFCD00003600

ID de substância PubChem:

24893738

NACRES:

NA.25

Nível de qualidade

200

teor

≥95%

forma

powder

pf

122-123 °C (lit.)

SMILES string

Cc1c2ccccc2c(C)c3c1ccc4ccccc34

InChI

1S/C20H16/c1-13-16-8-5-6-9-17(16)14(2)20-18(13)12-11-15-7-3-4-10-19(15)20/h3-12H,1-2H3

InChI key

ARSRBNBHOADGJU-UHFFFAOYSA-N

Descrição geral

7,12-Dimethylbenz[a]anthracene belongs to the category of polycyclic aromatic hydrocarbons. It is a carcinogenic organic pollutant generated from the incomplete combustion of gasoline and coal.

Aplicação

7,12-Dimethylbenz[a]anthracene was used:

to study the effects of Cimicifuga racemosa (CR) extract on the growth of mammary tumor induced by 7,12-Dimethylbenz[a]anthracene

in the study to compare the anti-carcinogenic properties of four red wine polyphenols as an initiator to cause skin cancer in CD-1 mouse model

to induce epithelial carcinogenicity in order to study the apoptotic, proliferating and p12^doc-1 profiles of normal, hyperplastic, dysplastic and malignant oral epithelium in the cheek pouch of the Syrian hamster

to cause mammary tumors to examine the causes and prevention of triacylglycerol accumulation in rat liver due to tamoxifen

Embalagem

100 mg in glass bottle

1, 5 g in glass bottle

Ações bioquímicas/fisiológicas

7,12-Dimethylbenz[a]anthracene has been found to be cytotoxic in nature, having carcinogenic properties. It also shows selective necrosis and hemorrhaging in the adrenal gland along with an inhibitory effect on plasma alkaline phosphatase levels. Its damaging effects are due to its ability to form charge transfer complexes by donating electrons to appropriate electron acceptors.