Propyl gallate antioxidant, ≥98.0% (HPLC)

Sinônimo(s):

3,4,5-Trihydroxybenzoic acid propyl ester

Fórmula linear:

3,4,5-(HO)₃C₆H₂CO₂CH₂CH₂CH₃

Número CAS:

121-79-9

Peso molecular:

212.20

Beilstein:

1877976

Número EC:

204-498-2

Número MDL:

MFCD00002196

eCl@ss:

39024506

ID de substância PubChem:

329757396

NACRES:

NA.77

Nível de qualidade

200

teor

≥98.0% (HPLC)

forma

solid

pf

146-149 °C (lit.)
146-149 °C

SMILES string

CCCOC(=O)c1cc(O)c(O)c(O)c1

InChI

1S/C10H12O5/c1-2-3-15-10(14)6-4-7(11)9(13)8(12)5-6/h4-5,11-13H,2-3H2,1H3

InChI key

ZTHYODDOHIVTJV-UHFFFAOYSA-N

Aplicação

Used as an anti-fade reagent in fluorescence microscopy to reduce photobleaching of fluorescent probes such as rhodamine and fluorescein.

Embalagem

100, 500 g

Ações bioquímicas/fisiológicas

An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO₄/GA as well as partially protect endothelial cells against TNF-induced apoptosis.

An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO₄/GA as well as partially protect endothelial cells against TNF-induced apoptosis. However, propyl gallate induced single strand breaks in DNA at concentrations higher than 0.25 μM when it was combined with copper concentrations at 5 μM and above. Another report, however, found that incubation of isolated rat hepatocytes with propyl gallate at concentrations of >1 mM induced cell killing, whereas, a lower concentration of propyl gallate > 0.5 mM resulted in a ladder formation of soluble low-molecular weight DNA fragments, characteristic of apoptosis.

Reconstituição

Prepare a 0.1M solution in glycerol:PBS (9:1)

Pictogramas

GHS05,GHS07,GHS09

Palavra indicadora

Danger

Frases de perigo

H302 - H317 - H318 - H410

Declarações de precaução

P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Classificações de perigo

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Sens. 1

Código de classe de armazenamento

13 - Non Combustible Solids

WGK

WGK 2

Ponto de fulgor (ºF)

368.6 °F - closed cup

Ponto de fulgor (ºC)

187 °C - closed cup

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves