Fmoc-Cys(Trt)-OH ≥95.0% (sum of enantiomers, HPLC)

Sinônimo(s):

N-(9-Fluorenylmethoxycarbonyl)-S-trityl-L-cysteine, N_α-Fmoc-S-trityl-L-cysteine

About This Item

Fórmula empírica (Notação de Hill):

C₃₇H₃₁NO₄S

Número CAS:

103213-32-7

Peso molecular:

585.71

Beilstein:

4221286

Número MDL:

MFCD00038538

Código UNSPSC:

12352209

eCl@ss:

32160406

ID de substância PubChem:

57651084

NACRES:

NA.26

Ensaio

≥95.0% (sum of enantiomers, HPLC)

atividade óptica

[α]20/D +16.0±2°, c = 1% in THF

adequação da reação

reaction type: Fmoc solid-phase peptide synthesis

pf

170-173 °C (lit.)

aplicação(ões)

peptide synthesis

grupo funcional

Fmoc

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

OC(=O)[C@H](CSC(c1ccccc1)(c2ccccc2)c3ccccc3)NC(=O)OCC4c5ccccc5-c6ccccc46

InChI

1S/C37H31NO4S/c39-35(40)34(38-36(41)42-24-33-31-22-12-10-20-29(31)30-21-11-13-23-32(30)33)25-43-37(26-14-4-1-5-15-26,27-16-6-2-7-17-27)28-18-8-3-9-19-28/h1-23,33-34H,24-25H2,(H,38,41)(H,39,40)/t34-/m0/s1

chave InChI

KLBPUVPNPAJWHZ-UMSFTDKQSA-N

Descrição geral

Fmoc-Cys(Trt)-OH is an amino acid commonly used in the Fmoc solid-phase peptide synthesis. [1]

Aplicação

Fmoc-Cys(Trt)-OH is an N-terminal protected cysteine derivative used in peptide synthesis. Some of the examples are:

• Synthesis of mono- and bi-functionalized platinum(IV) complexes to target angiogenic tumor vasculature.[2]

• Synthesis of proteins through native chemical ligation of peptide hydrazides as thioester surrogates via solid-phase synthesis.[3]

• Synthesis of glycoconjugates by conjugating reducing sugars to cysteine residues of peptides.[4]