Z-VAD-FMK ≥98% (TLC), solid, Caspase inhibitor

Sinônimo(s):

N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone

About This Item

Fórmula empírica (Notação de Hill):

C₂₂H₃₀FN₃O₇

Número CAS:

187389-52-2

Peso molecular:

467.49

Número MDL:

MFCD01074990

Código UNSPSC:

12352209

NACRES:

NA.77

Nome do produto

Z-VAD-FMK, solid

fonte biológica

synthetic

Ensaio

≥98% (TLC)

Formulário

solid

cor

white

solubilidade

DMSO: 20 mg/mL
H₂O: insoluble

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

FCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C)CC(=O)OC

InChI

1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1

chave InChI

MIFGOLAMNLSLGH-QOKNQOGYSA-N

Informações sobre genes

human ... CASP3(836)
mouse ... CASP3(12367)
rat ... CASP3(25402)

Descrição geral

Z-VAD-FMK inhibits yeast and mammalian peptide N-glycanase (PNGase).[1] It induces apoptosis. Z-VAD-FMK might be associated with endoplasmic reticulum (ER) stress.[2]

Aplicação

Z-VAD-FMK has been used:

• to induce mixed-lineage kinase domain-like (MLKL) phosphorylation (p-MLKL) in L929 cells[3]

• to induce autophagy in Jurkat and K562 cells[4]

• to revert killing effects of oxaliplatin or oxaliplatin combination with chloroquine (CQ) on HCT116 and SW620 cell lines[5]

• as a caspase inhibitor to inhibit apoptosis and assess nuclear factor-kB, heat shock protein 70 (Hsp 70), proto-oncogene (cmyc) and tumor suppressor protein p53[6]

Ações bioquímicas/fisiológicas

Non-selective, cell permeable inhibitor of caspase-1- and caspase-3-related proteases.

Características e benefícios

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Atenção

Hygroscopic