Hypoxanthine ≥99.0%

Sinônimo(s):

6-Hydroxypurine

About This Item

Fórmula empírica (Notação de Hill):

C₅H₄N₄O

CAS Number:

68-94-0

Peso molecular:

136.11

Beilstein:

5811

Número CE:

200-697-3

Número MDL:

MFCD00005725

Código UNSPSC:

41106305

ID de substância PubChem:

24895850

NACRES:

NA.51

fonte biológica

synthetic (organic)

Nível de qualidade

300

Ensaio

≥99.0%

Formulário

powder

pf

>300 °C (lit.)

solubilidade

formic acid: water (2:1): 50 mg/mL, clear to slightly hazy, colorless to yellow

cadeia de caracteres SMILES

O=C1NC=Nc2nc[nH]c12

InChI

1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)

chave InChI

FDGQSTZJBFJUBT-UHFFFAOYSA-N

Aplicação

Hypoxanthine is a nutrient additive for a variety of cell culture applications involving bacterial, parasite (Plasmodium falciparum) and animal cells. Hypoxanthine is a component of selection media used in hybridoma technologies.

Hypoxanthine has been used:

• to gavage mice and to evaluate the activity of xanthine oxidase (XO) in pasteurized whole milk in vivo in potassium oxonate (PO) -induced mouse model of hyperuricemia[1]

• as a supplement in Iscove′s modified Dulbecco′s medium (IMDM) medium to cultivate in-vitro cell line (EL-1 cells)[2]

• as a pure standard for the quantification of hypoxanthine in vitreous fluid sample using high-performance liquid chromatography-ultra-violet (HPLC-UV) for the estimation of post-mortem interval[3]

Ações bioquímicas/fisiológicas

Hypoxanthine acts as an intermediate in purine metabolism. It elicits a vital role as a 5′-base of the anticodon in a few transfer-RNAs. Though similar to guanine (Gua), it is devoid of the exocyclic amino group at C(2) position.[4] It may be used as a substrate to study the specificity and kinetics of hypoxanthine-guanine phosphoribosyl transferases.[5]