L-Thyroxine ≥98% (HPLC)

Sinônimo(s):

3,3′,5,5″-Tetraiodo-L-thyronine, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine, T₄

About This Item

Fórmula linear:

HOC₆H₂(I)₂OC₆H₂(I)₂CH₂CH(NH₂)CO₂H

CAS Number:

51-48-9

Peso molecular:

776.87

Beilstein:

2228515

Número CE:

200-101-1

Número MDL:

MFCD00002595

Código UNSPSC:

51111800

ID de substância PubChem:

24900033

NACRES:

NA.32

fonte biológica

synthetic

Nível de qualidade

200

esterilidade

non-sterile

Ensaio

≥98% (HPLC)

Formulário

powder

técnica(s)

cell culture | mammalian: suitable

pf

223 °C (dec.) (lit.)

solubilidade

4 M NH₄OH in methanol: 50 mg/mL, clear to hazy, yellow

Condições de expedição

ambient

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1

chave InChI

XUIIKFGFIJCVMT-LBPRGKRZSA-N

Informações sobre genes

human ... THRA(7067), THRB(7068), TTR(7276)
mouse ... Cnr2(12802)
rat ... Cnr1(25248)

Aplicação

L-Thyroxine was used to study the light-induced hormone conversion of T4 to T3 in regulation of photoperiodic response of gonads in Japanese quail.[1] The product was used as a test compound for studying the impact of numerous hormones on the surface morphology of rat testicular cells in culture.[2]

Ações bioquímicas/fisiológicas

L-Thyroxine (T₄) and triiodo-L-thyronine (T₃) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis.

L-Thyroxine is an iodine containing hormone produced from thyroglobulin in the thyroid follicular cells. L-Thyroxine reduces total cholesterol level, low-density lipoprotein cholesterol as well as waist to hip ratio in subclinical hypothyroidism pateints. Hence, facilitates in improving cardiovascular risk factor as well as can enhance symptoms of tiredness.[3]

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Nota de preparo

L-Thyroxine dissolves in 4M ammonium hydroxide in Methanol at 50 mg/ml to yield a clear to hazy yellow to dark yellow solution.