3,4-Dihydroxybenzoic acid

≥97.0% (T)

Sinônimo(s):

Protocatechuic acid

Sobre este item

Fórmula linear:

(HO)₂C₆H₃CO₂H

Número CAS:

99-50-3

Peso molecular:

154.12

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

57649743

EC Number:

202-760-0

Beilstein/REAXYS Number:

1448841

MDL number:

MFCD00002509

Assay:

≥97.0% (T)

InChI key

YQUVCSBJEUQKSH-UHFFFAOYSA-N

InChI

1S/C7H6O4/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,8-9H,(H,10,11)

SMILES string

OC(=O)c1ccc(O)c(O)c1

assay

≥97.0% (T)

Quality Level

200

functional group

carboxylic acid

General description

3,4-Dihydroxybenzoic acid is reported as dietery polyphenol.[1] Antiviral activity of 3,4-dihydroxybenzoic acid (protocatechuic acid, PCA) against a virulent H9N2 strain in a mouse model is reported.[2] Cytotoxic effects of PCA on 3 non-small cell lung cancer (NSCLC) cell lines, A549, H3255, and Calu-6 cell lines is reported.[3] PCA is reported to prevent the carcinogenesis or antitumor growth in vivo. Signaling pathway involved in PCA-induced apoptosis in human gastric adenocarcinoma (AGS) cells is reported.[4] The oxidation of 3,4-dihydroxybenzoic acid by H₂O₂ in aqueous/goethite slurry at varying operating conditions (catalyst load, temperature, pH, substrate and hydrogen peroxide starting concentration) is investigated.[5]

Application

3,4-Dihydroxybenzoic acid is suitable for use in a study to investigate the effect of 4-coumaric and 3,4-dihydroxybenzoic acid on the basal oxidative DNA damage of rat colonic mucosa in vivo.[1] It may be used in the derivatization of chitosan resin.[6]

Biochem/physiol Actions

Chemopreventive in several animal models of carcinogenesis. Blocks cell proliferation in the post-initiation phase.